2'3'-cGAMP (sodium salt)

2'3'-cGAMP (sodium salt)

Author: ApexBio

spu:

B8362

CAS:

1441190-66-4

purity:

0.98

shortsummary:

STING Ligand

buy (S)-(+)-Ibuprofen

Synonyms:

Guanosine-Adenosine 2',3'-cyclic monophosphate,2'-3'-Cyclic GMP-AMP

su 5416 Description

Formula:

C20H22N10Na2O13P2

M.Wt:

718.37

Chemical Name:

adenylyl-(3'→5')-2'-guanylic acid, cyclic nucleotide, disodium salt

SMILES:

O=P1([O-])O[C@]([C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O4)([H])[C@@]4([H])COP(O[C@@]5([H])[C@H](N6C=NC7=C6NC(N)=NC7=O)O[C@]([C@H]5O)([H])CO1)([O-])=O.[Na+].[Na+]

Solubility:

insoluble in EtOH; insoluble in DMSO; ≥7.56 mg/mL in H2O

Storage:

Store at -20°C

Physical Appearance:

A solid

DeliveryTime:

In stock

ALK5-TD

ShippingType:

Blue ice

description:

2’,3’-cGAMP (sodium salt) is a second messenger generated by the enzyme cGAMP synthase (cGAS) in the cytoplasm of mammalian cells, in response to the presence of double-stranded DNA.  As a second messenger, 2’,3’-cGAMP sodium salt activates innate immune responses via binding of STING (stimulator of IFN genes) and initiates the TBK1-IRF3-dependent production of IFN-β.

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