GDC-0068 (RG7440)

GDC-0068 (RG7440)

Author: ApexBio

spu:

A3006

CAS:

1001264-89-6

purity:

0.9906

shortsummary:

Pan-AKT inhibitor,highly selective

VX-765 In stock

Synonyms:

GDC0068,RG7440,CS0975

g418 working concentration

Formula:

C24H32ClN5O2

M.Wt:

458

Chemical Name:

(2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one

SMILES:

CC1CC(C2=C1C(=NC=N2)N3CCN(CC3)C(=O)C(CNC(C)C)C4=CC=C(C=C4)Cl)O

Solubility:

≥22.9 mg/mL in DMSO; insoluble in H2O; ≥28.35 mg/mL in EtOH

Storage:

Desiccate at -20°C

Physical Appearance:

A solid

DeliveryTime:

In stock

Suramin hexasodium salt Biological Activity

ShippingType:

Blue ice

description:

GDC-0068 (RG7440) is a highly selective small molecule inhibitor of Akt with IC50s of 5, 18 and 8 nM for Akt1, Akt2 and Akt3. The PI3K-AKT pathway regulates cell growth, survival and tumorigenesis. GDC-0068 binds to and blocks the activation of AKT, which result in cell cycle arrest, inhibition of tumor cell proliferation and induction of tumor cell death. PI3K-AKT is pathway frequently activated in tumors, thus tumors with PTEN or PI3K mutations, which lead to activation of AKT are with high sensitivity to GDC-0068. GDC-0068 is now used for the treatment of human cancers.

related websites:

APExBIO Technology LLC is a premier provider of Small Molecule Inhibitors/Activators, Compound Libraries, Peptides, Assay Kits, Fluorescent Labels, Enzymes, Modified Nucleotides, mRNA synthesis and various tools for Molecular Biology. We carry a broad product line in over 386 different research areas such as cancer, immunology, neurosciences, apoptosis and epigenetics etc. Based in USA (Houston, Texas), we have been serving the needs of customers across the world.