Duvelisib (IPI-145, INK1197)

Duvelisib (IPI-145, INK1197)

Author: ApexBio

spu:

A1720

CAS:

1201438-56-3

purity:

0.9955

shortsummary:

PI3K-δ/PI3K-γ inhibitor

Lonidamine Biological Activity

Formula:

C22H17ClN6O

M.Wt:

416.86

Chemical Name:

(S)-3-(1-((9H-purin-6-yl)amino)ethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one

SMILES:

O=C1N(C([C@H](C)NC2=C3N=CNC3=NC=N2)=CC4=C1C(Cl)=CC=C4)C5=CC=CC=C5

Solubility:

≥20.84 mg/mL in DMSO; insoluble in H2O; ≥24.9 mg/mL in EtOH

Storage:

Store at -20°C

Physical Appearance:

A solid

DeliveryTime:

In stock

S1P receptor inhibitor APExBIO

ShippingType:

Blue ice

description:

IPI-145 (also known as INK1197), an isoquinolinone derivative, is a small-molecule phosphoinositide-3 kinases (PI3K) inhibitor that selectively and potently inhibits two PI3K isoforms, PI3K-δ and PI3K-γ, with half maximal inhibition concentration IC50 of 2.5 nM and 27 nM respectively. Despite of preference for PI3K-δ and PI3K-γ, IPI-145 also inhibits other PI3K isoforms, PI3K-α and PI3K-β, to a lesser extent with IC50 of 1602 nM and 85 nM respectively.

related websites:

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